Twin sisters, Safa and Marwa Ullah, who were joined at the skull and blood vessels separated after 50 hour surgery at Great Ormond Street (GOSH), in London, began last October and the twins were finally detached on February 11 this year.

Twin sisters were brought to UK from Charsadda in Pakistan for operation along with their Zainab Bibi, 34, grandfather Mohammad Sadat Hussain, 57, and uncle, Mohammad Idrees.

Their father died of a heart attack while their mother was pregnant with them.

Neurosurgeon Noor ul Owase Jeelani and craniofacial surgeon Professor David Dunaway led the team which separated the girls using state-of-the-art technology.

Experts used virtual reality to create an exact replica of the girls’ anatomy to visualise the complex structure of their skulls, as well as how their brains and blood vessels were positioned.

Mum-of-nine Ms Bibi, from Charsadda in Pakistan, said: ‘We are indebted to the hospital and to the staff, and we would like to thank them for everything they have done. ‘We are extremely excited about the future.’

Great Ormond Street Hospital has previously successfully separated craniopagus twins — with their skulls and blood vessels fused together like Safa and Marwa – in 2006 and 2011.